Genes in the top networks altered by Indo, NS-398, and SC-560, identified by Ingenuity Pathway Analysis
NSAID | Genes in Network |
|---|---|
| Indo | Down-regulated |
| PTN (pleiotrophin), -4.0 | |
| TAGLN (transgelin), -3.6 | |
| NID (nidogen), -2.2 | |
| CXCL2 (chemokine (C-X-C motif) ligand 2), -2.1 | |
| H19 (H19 fetal liver mRNA), -2.1 | |
| CALD1 (caldesmon 1), -1.4 | |
| FST (follistatin), -1.2 | |
| SDC1 (syndecan 1), -1.1 | |
| PTMA (prothymosin α), -1.1 | |
| TNC (tenascin C), -1.1 | |
| SDC4 (syndecan 4), -1.0 | |
| Unchanged | |
| DNMT1 (DNA (cytosine-5-)-methyltransferase 1) | |
| FN1 (fibronectin 1) | |
| ROCK1 (Rho-associated coiled-coil forming kinase 1) | |
| INHBA (inhibin, β A) | |
| LGALS3BP (galectin-3 binding protein) | |
| Up-regulated | |
| BMP7 (bone morphogenetic protein 7), +2.4 | |
| CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), +2.3 | |
| CSPG2 (chondroitin sulfate proteoglycan 2), +2.0 | |
| FABP4 (fatty acid binding protein 4), +6.5 | |
| INHBE (inhibin, β E), +2.1 | |
| CAST (calpastatin), +1.4 | |
| GSN (gelsolin), +1.3 | |
| CASP3 (caspase 3), +1.1 | |
| IER3 (immediate early response 3), +1.1 | |
| MYC (myelocytomatosis viral oncogene), +1.1 | |
| RELA (v-rel reticuloendotheliosis viral oncogene homolog A), +1.1 | |
| NS-398 | Down-regulated |
| TAGLN (transgelin), -3.7 | |
| STX5A (syntaxin 5), -3.4 | |
| CAPN8, (calpain 8), -3.2 | |
| GPAM (glycerol-3-phosphate acyltransferase, mitochondrial), -2.8 | |
| PTN (pleiotrophin), -2.5 | |
| MAP3K12 (MAP kinase kinase kinase 12), -2.3 | |
| PIK3CA (phosphoinositide-3-kinase, catalytic, α polypeptide), -2,2 | |
| IGFPB6 (IGF binding protein 6), -2.1 | |
| RIN1 (Ras and Rab interactor 1), -2.1 | |
| PIAS2 (protein inhibitor of activated STAT, 2), -1.9 | |
| NRC31 [nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)], -1.6 | |
| SPARC (secreted protein, acidic, cysteine-rich (osteonectin)), -1.5 | |
| Scd2 (stearyl-coenzyme A desaturase 2), -1.3 | |
| CAPN2 (calpain 2), -1.2 | |
| CAPN5 (calpain 5), -1.2 | |
| FMR1 (fragile X mental retardation syndrome 1 homolog), -1.2 | |
| MTPN (Myotrophin), -1.2 | |
| PIK3CB (phosphatidylinositol 3-kinase, catalytic, β polypeptide), -1.2 | |
| CAPNS1 (calpain small subunit), -1.1 | |
| EDN1 (endothelin 1), -1.1 | |
| FASN (fatty acid synthase), -1.1 | |
| NRAS (neuroblastoma ras oncogene), -1.1 | |
| SREBF1 (sterol regulatory element binding factor 1), -1.1 | |
| Unchanged | |
| CAPN10 (calpain 10) | |
| RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) | |
| Up-regulated | |
| FABP4 (fatty acid binding protein 4), +2.6 | |
| IL6 (interleukin 6), +2.2 | |
| VEGF (vascular endothelial growth factor A), +2.0 | |
| MIF (macrophage migration inhibitory factor), +1.5 | |
| VCAM1 (vascular cell adhesion molecule 1), +1.3 | |
| MYC (myelocytomatosis viral oncogene), +1.2 | |
| PPID (peptidylprolyl isomerase D (cyclophilin D)), +1.1 | |
| RPS7 (ribosomal protein S7), +1.1 | |
| S100A6 (calcyclin), +1.1 | |
| SC-560 | Down-regulated |
| ITGB8 (integrin β 8), -2.9 | |
| ITGAV (integrin, α V), -1,1 | |
| Unchanged | |
| FN1 | |
| Up-regulated | |
|
| None |