Brain Region | Haloperidol | Clozapine |
---|---|---|
Cortical | ||
Prefrontal cortex | ⇆ | GRK2 ↑ pERK ↑ |
Cingulate cortex | ⇆ | ⇆ |
Dorsal hippocampus | ⇆ | ARR2 ↓ GRK3 ↓ |
Basal ganglia | ||
Nucleus accumbens core | ⇆ | ARR2 ↑ |
Nucleus accumbens shell | ⇆ | ⇆ |
Caudatoputamen dorsomedial | ⇆ | ⇆ |
Caudatoputamen dorsolateral | ⇆ | ⇆ |
Caudatoputamen ventromedial | ⇆ | ⇆ |
Caudatoputamen ventrolateral | GRK3 ↓ | ARR2 ↑ pERK ↑ |
Caudal caudatoputamen | GRK5 ↓ (2h) | GRK5 ↓ (2 h) ↑ (24 h) |
Globus pallidus | GRK5 ↓ (2h) | GRK5 ↓ (2 h) GRK3 ↓ |
U, no significant differences; ↓ or ↑, a protein was significantly decreased or increased in the drug-treated as compared with the vehicle-treated group; (2 h) or (24 h), the protein was altered 2 or 24 h after the last injection; otherwise, the changes were detected with both washout periods.