Day 1 | Day 2 | Day 4 | Day 8 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | Placebo | Baseline | LS1 (0.025 mg/kg) | Baseline | LS2 (0.05 mg/kg) | Baseline | LS3 (0.1 mg/kg) | |||||
Normal (n = 9) | ||||||||||||
EES (mm Hg/ml) | 5.6 ± 1.3 | 5.7 ± 0.2 | 5.6 ± 1.3 | 8.2 ± 1.9*† | 5.6 ± 1.3 | 10.5 ± 1.9*†‡ | 5.6 ± 1.3 | 12.6 ± 2.7*†‡§ | ||||
MSW (mm Hg) | 69.9 ± 7.4 | 68.2 ± 7.9 | 68.9 ± 9.4 | 86.3 ± 4.9*† | 67.0 ± 6.9 | 90.8 ± 12.0*† | 70.9 ± 7.0 | 99.2 ± 9.2*†‡ | ||||
EES/Ea | 0.61 ± 0.13 | 0.62 ± 0.16 | 0.63 ± 0.18 | 0.98 ± 0.25*† | 0.62 ± 0.11 | 1.36 ± 0.32*†‡ | 0.63 ± 0.16 | 1.50 ± 0.46*†‡ | ||||
SW/PVA | 0.58 ± 0.05 | 0.58 ± 0.06 | 0.58 ± 0.07 | 0.68 ± 0.06*† | 0.58 ± 0.04 | 0.75 ± 0.05*†‡ | 0.58 ± 0.06 | 0.77 ± 0.05*†‡ | ||||
HF (n = 7) | ||||||||||||
EES, mm Hg/ml | 3.6 ± 0.8 | 3.7 ± 0.9 | 3.7 ± 0.8 | 5.7 ± 1.1*† | 3.7 ± 0.7 | 7.1 ± 1.6*†‡ | 3.6 ± 0.8 | 8.7 ± 1.5*†‡§ | ||||
MSW, mm Hg | 42.7 ± 3.7 | 43.8 ± 6.5 | 44.9 ± 3.7 | 58.5 ± 4.9*† | 44.3 ± 5.1 | 65.1 ± 5.2*†‡ | 43.7 ± 5.5 | 70.3 ± 6.1*†‡ | ||||
EES/Ea | 0.32 ± 0.07 | 0.33 ± 0.08 | 0.31 ± 0.06 | 0.61 ± 0.14*† | 0.32 ± 0.07 | 0.78 ± 0.27*† | 0.32 ± 0.07 | 0.94 ± 0.32*†‡ | ||||
SW/PVA | 0.44 ± 0.07 | 0.44 ± 0.06 | 0.43 ± 0.06 | 0.59 ± 0.05*† | 0.43 ± 0.06 | 0.63 ± 0.08*† | 0.43 ± 0.05 | 0.67 ± 0.07*†‡§ |