TABLE 2

ED50 values for inhibition of plasma DPP-4 activity in HanWistar rats at different times after dosing



ED50 Values

BI 1356
Saxagliptin
Alogliptin
Vildagliptin
Sitagliptin
mg / kg
7 h Postdose 0.3 0.1 0.1 0.5 2.3
24 h Postdose 0.9 2.7 10 14 >30
Ratio 24/7 h
3
27
100
28
>13