TABLE 1

Selectivity of BI 1356 versus various other peptidases and proteases




IC50 Values of Triplicate Determinations
nM
DPP-2 >100,000
DPP-8 40,000
DPP-9 >10,000
FAP 89
Aminopeptidase N >100,000
Aminopeptidase P >10,000
Prolyloligopeptidase >100,000
Trypsin >100,000
Plasmin >100,000
Thrombin
>100,000