TABLE 1

Pharmacokinetic parameters of plasma nicotine in mice treated i.p. with nicotine (1 mg/kg) or nicotine plus selegiline (1 mg/kg)

Results were derived using data (Fig. 3) from three to six animals at each time point.

-SEL
+SEL
Mean ± S.D.
AUC0-40 (ng/h/ml) 57.4 ± 5.3 90.7 ± 5.8*
t1/2 (min) 6.6 ± 1.4 12.5 ± 6.3*
CL/F (ml/min)
7.3 ± 0.3
4.6 ± 0.4*

  • ↵* p < 0.05 compared to -SEL.