TABLE 1

SD-282 (90 mg/kg p.o. b.i.d.) prevents inflammatory responses in A/J mice induced by 11 daily consecutive tobacco smoke exposures, and dexamethasone (0.3 mg/kg p.o. b.i.d.) fails to prevent inflammatory responses in A/J mice induced by 11 daily consecutive tobacco smoke exposures

Data are presented as mean ± S.D. (105 cells). Statistical analysis compared with the vehicle group and subjected to ANOVA, followed by Bonferroni's correction for multiple comparisons, is shown.

Inflammatory Markers
Air
Vehicle
Treatment
SD-282 (90 mg/kg b.i.d.)
Total cells 0.61 ± 0.26 3.86 ± 1.32 2.23 ± 0.91*
Macrophages 0.61 ± 0.28 3.79 ± 1.39 2.22 ± 0.96*
Neutrophils 0 ± 0 0.08 ± 0.03 0.014 ± 0.15**
BAL protein 0.20 ± 0.04 0.38 ± 0.05 0.24 ± 0.08**
BAL KC 16 ± 3.3 40.5 ± 12 24.9 ± 6*
Dexamethasone (0.3 mg/kg b.i.d.)
Total cells 0.22 ± 0.09 1.63 ± 0.34 1.84 ± 0.54*
Macrophages 0.22 ± 0.09 1.33 ± 0.25 1.40 ± 0.50*
Neutrophils
0 ± 0
0.19 ± 0.12
0.26 ± 0.17*

  • For SD-282, * p < 0.01 and ** p < 0.001 compared with the vehicle group. Dexamethasone failed to significantly inhibit TS-induced increases in BAL cells; * p is not significant compared with the vehicle group.