Parameter | Value | CV |
---|---|---|
% | ||
Structural parameters | ||
CL (ml min-1) | 11.9 | 3.8 |
V1 (ml) | 112 | 8.3 |
Q2 (ml min-1) | 15.3 | 8.0 |
V2 (ml) | 171 | 8.7 |
Q3 (ml min-1) | 8.73 | 4.8 |
V3 (ml) | 857 | 4.7 |
Interanimal variability | ||
ωCL2 | 0.0359 | 21 |
ωV22 | 0.158 | 30 |
ωV32 | 0.0230 | 37 |
ωCL,V32 (covariance) | 0.0251 | 38 |
Residual error | ||
σPK2 | 0.0265 | 9.9 |
V1, volume of distribution of the central compartment; Q2, intercompartmental clearance to the second compartment; V2, volume of distribution of the second compartment; Q3, intercompartmental clearance to the third compartment; V3, volume of distribution of the third compartment; ω, interindividual variability; σ, residual variability.