Parameter | Value | CV |
---|---|---|
% | ||
Structural parameters | ||
E0 (bpm) | 373 | 1.8 |
DEC (h-1) | 2.1 | 39 |
Emax (bpm)a | 130 | (5.9) |
τb | 247 | (34) |
KA = Ki (ng ml-1)b | 6.33 | FIX |
KB | 12.9 | 24 |
nH | 1.74 | 18 |
36.6 | 17 | |
77.7 | 37 | |
Interanimal variability | ||
ωDEC2 | 1210 | 24 |
ωE02 | 25.4 | 29 |
ωEmax2 | 1320 | 29 |
ωKB2 | 1.14 | 36 |
Residual error | ||
σPD | 829 | 28 |
E0, baseline heart rate; DEC, linear decrease over time; , concentration that causes half-maximal effect for baseline model; , maximal decrease due to displacement of endogenous agonist; ω, interindividual variability; σ, residual variability.
↵ a Parameter estimated using the Emax model and fixed in the agonist-antagonist interaction model.
↵ b Parameter obtained from literature and fixed in the agonist-antagonist interaction model.