Plasma DCA kinetics in humans
Subjects received 12.5 mg/kg DCA. Data are mean ± S.D. of results obtained after the first DCA dose and after 6 months of daily exposure to 12.5 mg/kg every 12 h. Kinetic parameters were determined from a noncompartmental pharmacokinetic model using WinNonLin software, version 5.01.
Parameter | First Dose | Six Months | ||||
|---|---|---|---|---|---|---|
| Children | Adults | Children | Adults | |||
| No. subjects | 5 | 4 | 5 | 4 | ||
| Age (yr) | 5.2 ± 1.8 | 24 ± 10 | 5.7 ± 1.8 | 24.5 ± 10 | ||
| t1/2 (h) | 2.5 ± 0.4 | 2.1 ± 1.5 | 6.4 ± 3.4 | 21 ± 5.8 | ||
| Cmax (μg/ml) | 23 ± 9.1 | 25 ± 6.6 | 35 ± 10 | 53 ± 18 | ||
| AUC0-∞ (μg/ml · h) | 83 ± 33 | 70 ± 18 | 340 ± 130 | 1500 ± 700 | ||
| Clearance | 150 ± 60 | 180 ± 46 | 37 ± 14 | 8.3 ± 4.6 | ||