TABLE 1

Inhibitory potency of relaxant nucleotides

The potency of relaxant nucleotides on carbachol-precontracted taenia muscle strips in the absence of antagonists (control data), presence of MRS2179 alone, or MRS2179 with A317491 (antagonist data) and further addition of ADA (deaminase data). Data are given as mean EC₅₀ values and Hill slopes (n_H) for four experiments.

	ATP			BzATP
	Mean EC₅₀	n_H	Mean EC₅₀	n_H	Mean EC₅₀	n_H
	μM		μM		μM
Control	0.04^a	1.99^a	2.96	2.38	2.00	2.50
	10.3^b	0.91^b
+ MRS2179	32.6	0.96	77.2	0.95	46.7	0.86
+ MRS2179 and A317491	38.3	1.11	218.9	0.93	173.4	1.06
+ MRS2179, A317491, and ADA	5.70	1.17	6.60	1.15	66.6	0.95

ATP data were analyzed for first^a and second^b phases of the control C/R curve.