Pharmacokinetics of orally and intravenously administered LJP 1586 in rats
Parameter (Units) | Oral (5 mg/kg) | Intravenous (1 mg/kg) |
|---|---|---|
| T1/2 (min)a | 86 ± 6b | 105 ± 15 |
| Tmax (min) | 26 ± 6 | 5c |
| Cmax (ng/ml) | 85 ± 26 | 424 ± 66c |
| CL (ml/min/kg) | 540 ± 67d | 77 ± 2 |
| Vz (ml/kg) | N.D. | 11,675 ± 1997 |
| Vss (ml/kg) | N.D. | 5055 ± 964 |
| AUCALL (min × ng/ml) | 8903 ± 1166 | 12,404 ± 546 |
| AUCINF (min × ng/ml) | 9556 ± 1180 | 13,101 ± 407 |
↵ a T1/2, elimination half-life; Tmax, time of maximal observed plasma concentration; Vz, volume of distribution; Vss, volume of distribution at steady state; AUCALL, area under concentration-time curve from time of dosing to the time of last observation; AUCINF, area under concentration-time curve from time of dosing, extrapolated to infinity
↵ b Means ± S.E.M. of three rats per group
↵ c Earliest point examined
↵ d Calculated from dose p.o./AUCINF p.o.