TABLE 1

Discriminative stimulus and rate effects of drugs in monkeys discriminating between saline and 0.32 mg/kg DOM

Dose
% Drug-Lever ± S.E.M.
Rate ± S.E.M.
mg / kg response / s
Compound
Saline 0 ± 0 1.21 ± 0.09
Amphetamine 0.178 0 ± 0 2.14 ± 0.27
0.32 5 ± 3 1.82 ± 0.37
0.56 0 ± 0 1.55 ± 0.16
1.0 5 ± 3 1.50 ± 0.37
1.78 0 ± 0 1.78 ± 0.19
Cocaine 0.56 3 ± 1 1.85 ± 0.07
1.0 4 ± 2 1.46 ± 0.14
1.78 1 ± 1 1.91 ± 0.24
3.2 0 ± 0 1.92 ± 0.36
Fenfluramine 1.0 3 ± 3 0.82 ± 0.23
3.2 1 ± 1 0.53 ± 0.15
10 18 ± 18 0.45 ± 0.11
Ketamine 1 13 ± 7 0.91 ± 0.32
1.78 21 ± 10 1.08 ± 0.32
3.2 38 ± 16 0.57 ± 0.09
5.6 8 ± 8 0.36 ± 0.15
10 N.D. 0 ± 0
Methamphetamine 0.32 0 ± 0 1.66 ± 0.07
0.56 0 ± 0 1.96 ± 0.27
1.0 0 ± 0 1.34 ± 0.16
Morphine 1.78 1 ± 1 1.24 ± 0.28
3.2 10 ± 10 1.01 ± 0.30
5.6 0 ± 0 1.59 ± 0.58
10 4 ± 4 1.56 ± 0.30
N-0434 0.032 1 ± 1 1.24 ± 0.29
0.1 4 ± 4 2.07 ± 0.31
0.178 2 ± 2 2.10 ± 0.35
Phencyclidine 0.1 3 ± 2 0.85 ± 0.12
0.178 15 ± 14 1.13 ± 0.12
0.32 45 ± 13 0.41 ± 0.25
Salvinorin A 0.0032 0 ± 0 1.47 ± 0.09
0.0056 0 ± 0 1.63 ± 0.15
0.01 0 ± 0 1.71 ± 0.13
0.0178 1 ± 1 1.94 ± 0.23
0.032 1 ± 1 1.71 ± 0.29
0.056 0 ± 0 1.45 ± 0.19
0.1 9 ± 5 0.71 ± 0.08
U-50488 0.1 1 ± 1 1.58 ± 0.45
0.178 0 ± 0 1.62 ± 0.33
0.32 6 ± 3 1.37 ± 0.41
0.56 2 ± 2 0.55 ± 0.15
1 0 ± 0 0.45 ± 0.14
Yohombine 0.032 0 ± 0 0.91 ± 0.20
0.056 1 ± 1 1.21 ± 0.33
0.1 17 ± 17 1.14 ± 0.37
0.178 0 ± 0 1.13 ± 0.21
0.32 0 ± 0 1.13 ± 0.06
0.56 0 ± 0 1.10 ± 0.30
1.0 0 ± 0 1.10 ± 0.15
8-OH-DPAT 0.1 0 ± 0 1.35 ± 0.37
0.178 0 ± 0 1.25 ± 0.50
0.32
0 ± 0
0.09 ± 0.06

  • N.D., not determined