Inhibitory effect of anti-CCR2 antibody on macrophages and eosinophils in BAL fluid from Ascaris suum-challenged monkeys Results are expressed as the mean ± S.E.M. of the x-fold increase in total cell numbers. Significant difference between CCR2-05-treated monkeys and control or mIgG2b-treated monkeys is indicated.
Cells in BAL | Treatment | 3 h | 24 h |
|---|---|---|---|
| Macrophages | Control | 1.738 ± 0.306 | 2.588 ± 0.568 |
| mIgG2b | 1.650 ± 0.536 | 1.625 ± 0.189 | |
| CCR2–05 | 1.275 ± 0.155 | 1.150 ± 0.343 | |
| Eosinophils | Control | 2.550 ± 0.495 | 11.830 ± 1.719 |
| mIgG2b | 2.325 ± 0.340 | 12.500 ± 1.783 | |
|
| CCR2–05 | 1.500 ± 0.071 | 3.600 ± 0.537** |
↵** , P < 0.01, one-way ANOVA test