TABLE 1

Effect of LA-419 on food consumption, body weight, blood leukocytes, and TNF during the acute phase (day 4) of indomethacin-induced enteritis in rats Data are expressed as means ± S.E.M. (n = 12).

Group
Food Consumption
Body Weight Gain
Leukocytes
TNF
g % cells/mm3 pg/ml
Control 25.3 ± 2.6 7.2 ± 1.7 11,713 ± 1059 <4
LA-419 26.2 ± 2.2 6.9 ± 1.5 12,917 ± 1059 <4
INDO 13.6 ± 2.8 –7.2 ± 1.3 22,033 ± 1695 82.8 ± 12.6
INDO + LA-419
19.5 ± 3.9**
–3.7 ± 1.3**
18,429 ± 1370**
47.5 ± 9.3*

  • ↵* P < 0.05

  • ↵** P < 0.01 vs. inflamed control (INDO) group