Predicted additive ED50 values (Zadd) and experimentally determined ED50 values (Zmix) of morphine + mGlu receptor antagonist mixtures in the assay of schedule-controlled responding
Drug Mixture | Zadd (95% CL) | Zmix (95% CL) |
|---|---|---|
| JNJ16259685 + morphine | ||
| 0.29:1 JNJ16259685/morphine | 1.7 (1.3–2.3) | 3.1 (1.8–5.3) |
| 0.87:1 JNJ16259685/morphine | 3.5 (2.3–5.3) | 3.1 (2.0–4.9) |
| 2.6:1 JNJ16259685/morphine | 3.1 (2.7–3.6) | 3.0 (2.0–4.5) |
| MPEP + morphine | ||
| 1.9:1 MPEP/morphine | 4.7 (2.1–11) | 6.1 (3.9–9.4) |
| 5.7:1 MPEP/morphine | 6.9 (3.2–15) | 9.5 (6.1–15) |
| 17:1 MPEP/morphine | 14 (5.5–35) | 13 (8.2–21) |
| LY341495 + morphine | ||
| 0.31:1 LY341495/morphine | 3.4 (2.0–5.9) | 3.3 (2.2–4.9) |
| 0.93:1 LY341495/morphine | 2.9 (1.7–5.1) | 3.3 (2.2–5.0) |
| 2.8:1 LY341495/morphine | 2.7 (1.3–5.6) | 3.1 (2.0–4.9) |
CL, confidence limit