TABLE 1

Effect of selective A2B antagonists on IL-6 release (picogram/milligram) from peritoneal macrophages The selective A2B antagonists IPDX (10 μM), MRS 1754 (1 μM), or their vehicle were added to cells, which were then incubated in the absence (Basal) or presence of 10 μM NECA for 16 h. Data are the mean ± S.E.M. of five separate cell preparations. Asterisks indicate significant difference from vehicle.




Vehicle

IPDX

MRS 1754
pg/mg
Basal 64.2 ± 4.86 62.3 ± 11.4 60.3 ± 13.4
NECA
371.8 ± 22.9
105.8 ± 19.4**
103.9 ± 16.8**
  • ** p < 0.01, one-way ANOVA with the Dunnett's post-test