TABLE 1

List of chemicals, dosing regimen, and known target transcription factors

Compound
Dose
Vehicle
Route
AhR ligands
    TCDD 34 μg/kg Corn oil i.p.
    PCB126 300 μg/kg Corn oil i.p.
    BNF 200 mg/kg Corn oil i.p.
CAR activators
    TCPOBOP 300 μg/kg Corn oil i.p.
    DAS 200 mg/kg Corn oil i.p.
    Phenobarbital 100 mg/kg Saline i.p.
PXR ligands
    PCN 200 mg/kg Corn oil i.p.
    SPR 200 mg/kg Corn oil i.p.
    DEX 75 mg/kg Corn oil i.p.
PPARα ligands
    CLOF 500 mg/kg Corn oil i.p.
    Ciprofibrate 40 mg/kg Corn oil i.p.
    Diethylhexylphthalate 1000 mg/kg Corn oil p.o.
Nrf2 activators
    OPZ 150 mg/kg Corn oil p.o.
    EXQ 250 mg/kg Corn oil p.o.
    BHA
350 mg/kg
Corn oil
i.p.