Atorvastatin-induced total cholesterol lowering and tissue levels of drug in guinea pig
Atorvastatin Dose | Number of Animals Analyzed per Group of 8 | TC ± S.D.a | Drug Levelsd | ||||||
|---|---|---|---|---|---|---|---|---|---|
| TC | Plasma | Liver | Muscle | ||||||
| Percentage Loweringb | Mean ± S.D. (Ratio)c | Mean ± S.D. (Ratio) | Mean ± S.D. (Ratio) | ||||||
| μM | |||||||||
| 0 mg/kg | 8/8 | 43.1 ± 12.3 | |||||||
| 25 mg/kg | 8/8 | 27.1 ± 8.5 | 37.1 | 0.51 ± 0.27 (1) | 7.5 ± 2.8 (14.7) | 0.02 ± 0.01 (<0.1) | |||
| 50 mg/kg | 8/8 | 22.3 ± 4.3 | 48.4 | 0.72 ± 0.46 (1) | 11.1 ± 7.9 (15.4) | 0.05 ± 0.03 (<0.1) | |||
| 100 mg/kg | 8/8 | 15.8 ± 4.0 | 63.5 | 3.14 ± 1.67 (1) | 20.4 ± 8.2 (6.5) | 0.17 ± 0.09 (<0.1) | |||
| 150 mg/kg | 8/8e | 15.9 ± 3.5 | 63.2 | 6.91 ± 5.40 (1) | 22.3 ± 8.7 (3.2) | 0.33 ± 0.28 (<0.1) | |||
| 200 mg/kg | 3/8f | 16.0 ± 6.9 | 62.9 | 26.50 ± 19.92 (1) | 54.3 ± 48.4 (2.0) | 6.05 ± 7.07 (0.23) | |||
| 250 mg/kg | 7/8g | 13.7 ± 7.1 | 68.2 | 38.57 ± 86.89 (1) | 47.0 ± 52.9 (1.2) | 13.41 ± 30.68 (0.35) | |||
| 1.2 mg/kg Cerivastatin | 8/8 | 24.8 ± 10.5 | 42.6 | N.D. | N.D. | N.D. | |||
↵ a mean plasma TC values in milligram/deciliter.
↵ b Relative to vehicle mean.
↵ c Relative to mean plasma drug level set to one.
↵ d Values represent sum total of parent, ortho-, and para-hydroxy metabolites.
↵ e Two animals were declared moribund on day 6; samples were collected before euthanization.
↵ f Five animals died prematurely, and no samples were collected; one animal was declared moribund on day 6, and sample was collected before euthanization.
↵ g One animal died prematurely, and no sample was collected; one animal was declared moribund on day 6, two animals were declared moribund on day 7, and two animals were declared moribund on day 8, and samples were collected before euthanization.