TABLE 4

Rosuvastatin-induced total cholesterol lowering and tissue levels of drug in guinea pig


Rosuvastatin Dose

TC ± S.D.a

TC Percentage Loweringb

Drug Levels
Plasma
Liver
Muscle
Mean ± S.D. (Ratio)c
Mean ± S.D. (Ratio)
Mean ± S.D. (Ratio)
nM
0 mg/kg 50.9 ± 9.4
10 mg/kg 35.1 ± 3.9 31.0 179 ± 50 (1) 444 ± 169 (2.5) 25 ± 21 (0.14)
25 mg/kg 31.3 ± 7.3 38.6 519 ± 129 (1) 1022 ± 406 (2.0) 108 ± 77 (0.21)
50 mg/kg 25.6 ± 6.9 49.6 951 ± 206 (1) 1412 ± 353 (1.3) 83 ± 21 (0.08)
75 mg/kg 26.5 ± 6.5 47.9 2140 ± 1470 (1) 3385 ± 1386 (1.5) 182 ± 72 (0.09)
100 mg/kg
23.3 ± 6.9
54.3
3626 ± 2286 (1)
2536 ± 1477 (0.7)
276 ± 103 (0.08)
  • a n = 8 per group; mean plasma TC values in milligram/deciliter.

  • b Relative to vehicle mean.

  • c Relative to mean plasma drug level set to one.