BMS-423526 Dose | TC ± S.D.a | TC Percent Loweringb | Drug Levels | ||||
---|---|---|---|---|---|---|---|
Plasma | Liver | Muscle | |||||
Mean ± S.D. (Ratio)c | Mean ± S.D. (Ratio) | Mean ± S.D. (Ratio) | |||||
nM | |||||||
0 mg/kg | 47.8 ± 3.6 | ||||||
0.25 mg/kg | 30.5 ± 9.5 | 36.1 | 618 ± 135 (1) | 1346 ± 596 (2.2) | 49 ± 13 (0.08) | ||
0.5 mg/kg | 25.5 ± 2.1 | 46.6 | 1227 ± 289 (1) | 2352 ± 629 (1.9) | 88 ± 25 (0.07) | ||
1.0 mg/kg | 20.5 ± 8.9 | 57.1 | 3363 ± 489 (1) | 4347 ± 849 (1.3) | 178 ± 38 (0.05) | ||
1.5 mg/kg | 22.9 ± 5.1 | 52.1 | 4213 ± 2075 (1) | 6261 ± 1518 (1.5) | 182 ± 59 (0.04) | ||
2.0 mg/kg | 24.0 ± 10.7 | 49.7 | 4643 ± 958 (1) | 8771 ± 1895 (1.9) | 416 ± 125 (0.09) |