TABLE 2

Cerivastatin-induced total cholesterol lowering and tissue levels of drug in guinea pig


Cerivastatin Dose

TC ± S.D.a

TC Percent Loweringb

Drug Levels
Plasma
Liver
Muscle
Mean ± S.D. (Ratio)c
Mean ± S.D. (Ratio)
Mean ± S.D. (Ratio)
nM
0 mg/kg 56.4 ± 12.3
0.1 mg/kg 43.8 ± 10.3 22.3 24 ± 23 (1) 158 ± 108 (6.6) ≤LLQd
0.3 mg/kg 40.2 ± 7.3 28.7 33 ± 33 (1) 425 ± 407 (12.9) 13 ± 20 (0.4)
0.6 mg/kg 32.8 ± 9.6 41.8 170 ± 124 (1) 1203 ± 805 (7.1) 46 ± 44 (0.3)
1.2 mg/kg
28.4 ± 9.1
49.6
292 ± 292 (1)
1416 ± 1041 (4.8)
101 ± 92 (0.3)
  • a n = 5 per treatment group; mean plasma TC values in milligram/deciliter.

  • b Relative to vehicle mean.

  • c Relative to mean plasma drug level set to one.

  • d Lower limits of quantitation.