Biological pathways significantly impacted by A-875400 (R), A-908292 (S), and bezafibrate in rat liver
Pathway | Compound | No. of Regulated Genes in Pathway | Total No. of Genes in Pathway | Intersection | p Value |
|---|---|---|---|---|---|
| % | |||||
| PPAR-α and fatty acid metabolism | A-875400 (R) | 11 | 47 | 23.4 | 7.0E-6 |
| A-908292 (S) | 12 | 47 | 25.5 | 1.0E-7 | |
| Bezafibrate | 16 | 47 | 34.0 | 6.2E-12 | |
| Bile acid and cholesterol metabolism | A-875400 (R) | 11 | 54 | 20.4 | 2.9E-5 |
| A-908292 (S) | 14 | 54 | 25.9 | 7.3E-9 | |
| Bezafibrate | 15 | 54 | 27.8 | 7.5E-10 | |
| Regulation of fatty acid biosynthesis | A-875400 (R) | 10 | 58 | 17.2 | 2.8E-4 |
| A-908292 (S) | 11 | 58 | 19.0 | 8.4E-6 | |
| Bezafibrate | 12 | 58 | 20.7 | 1.3E-6 | |
| Fatty acid biosynthesis | A-875400 (R) | 4 | 16 | 25.0 | 5.2E-3 |
| A-908292 (S) | 6 | 16 | 37.5 | 1.5E-5 | |
| Bezafibrate | 6 | 16 | 37.5 | 1.5E-5 | |
| β-Oxidation of fatty acid | A-875400 (R) | 3 | 22 | 13.6 | 4.7E-2 |
| A-908292 (S) | 4 | 22 | 18.2 | 8.3E-3 | |
|
| Bezafibrate | 3 | 22 | 13.6 | 4.7E-2 |