TABLE 1

Plasma concentrations of PSI-697 in models of inflammation and thrombosis


Model

Dose

Time Point

Average Concentration

S.E.
mg/kg min ng/ml
Acute surgical inflammation 50 60 35774 5480
30 60 5995 983
100 60 3386 312
Venous thrombosis 100 120 821 205
30 60 1163 16
30 120 280 63
Rat carotid balloon injury 30 1440 30 18
15 1440 17 10

3
1440
14
6