Histological and molecular results at 3 months in sham-operated rats and aortic-banded rats treated or not treated with ivabradine mRNA levels are given in arbitrary units.
Shams (n = 6-9) | Aortic-Banded Rats | |||
|---|---|---|---|---|
| Untreated (n = 8-15) | Ivabradine, 10 mg/kg/day (n = 10-15) | |||
| LV fibrosis score (0-9) | 0** | 5.2 ± 0.2 | 6.4 ± 0.3* | |
| Atrial natriuretic peptide mRNA level | 0.08 ± 0.02* | 1.23 ± 0.16 | 1.88 ± 0.19** | |
| SERCA2a mRNA level | 1.23 ± 0.10 | 1.42 ± 0.13 | 1.05 ± 0.09* | |
| RyR2 mRNA level | 1.09 ± 0.24 | 0.83 ± 0.09 | 0.71 ± 0.13 | |
| Phospholamban mRNA level | 0.97 ± 0.11 | 0.92 ± 0.09 | 0.85 ± 0.08 | |
| Citrate synthase (IU/g prot) | 730 ± 66 | 631 ± 42 | 528 ± 46 | |
| Cytochrome c oxidase (IU/g prot) | 846 ± 110 | 793 ± 58 | 783 ± 102 | |
| Creatine kinase (IU/g prot) | 4387 ± 248* | 3162 ± 333 | 3218 ± 301 | |