Echographic and hemodynamic values at 3 months in sham-operated rats and in aortic-banded rats treated or not treated with ivabradine
Shams (n = 12-16) | Aortic-Banded Rats | |||
|---|---|---|---|---|
| Untreated (n = 17-27) | Ivabradine, 10 mg/kg/day (n = 16-29) | |||
| Heart rate (beats/min) | 330 ± 7 | 347 ± 6 | 281 ± 6** | |
| LVEDD/BW (mm/kg) | 21.8 ± 0.6** | 24.2 ± 0.5 | 25.6 ± 0.7 | |
| IVS thickness (mm) | 0.96 ± 0.03** | 1.86 ± 0.03 | 1.93 ± 0.03 | |
| IVS thickness/LVEDD | 0.18 ± 0.01** | 0.33 ± 0.01 | 0.33 ± 0.01 | |
| Cardiac output (ml/min) | 216 ± 6** | 134 ± 4 | 127 ± 5 | |
| Stroke volume/BW (μl/g) | 1.27 ± 0.05** | 0.83 ± 0.02 | 1.06 ± 0.03** | |
| Ejection time (ms) | 76 ± 6* | 89 ± 4 | 98 ± 6* | |
| Stroke volume/ejection time | 8.6 ± 0.7* | 4.3 ± 0.6 | 4.5 ± 0.8 | |
| LV shortening fraction (%) | 41 ± 1** | 27 ± 1 | 27 ± 1 | |
| Sa (cm/s) | 4.61 ± 0.14** | 2.79 ± 0.10 | 2.68 ± 0.09 | |
| strain rate (s-1) | 11.61 ± 0.41* | 8.35 ± 0.32 | 7.43 ± 0.21 | |
| E/Ea | 15 ± 1** | 23 ± 1 | 31 ± 2** | |
| Isovolumic relaxation time (ms) | 22.0 ± 0.7** | 14.5 ± 0.8 | 11.6 ± 0.6** | |
| Systolic LVP (mm Hg) | 119 ± 6* | 203 ± 9 | 226 ± 22 | |
| LVEDP (mm Hg) | 1.8 ± 0.4* | 3.2 ± 0.4 | 7.8 ± 1.2** | |
| dP/dt max (mm Hg · s-1) | 7595 ± 120 | 8309 ± 102 | 7831 ± 319 | |
| dP/dt min (mm Hg · s-1) | 6280 ± 243 | 6420 ± 110 | 6281 ± 200 | |