TABLE 1

Echocardiographic parameters in mice chronically injected with DOX and EPO

Placebo + Vehicle
Placebo + EPO
DOX + Vehicle
DOX + EPO
HR (bpm) 507 ± 23 506 ± 17 417 ± 10† 500 ± 20**
Anterior wall thickness (mm) 0.77 ± 0.02 0.74 ± 0.02 0.69 ± 0.04 0.74 ± 0.02
Posterior wall thickness (mm) 0.77 ± 0.04 0.74 ± 0.01 0.69 ± 0.04 0.78 ± 0.03
Left ventricular end-diastolic dimension (mm) 4.23 ± 0.12 4.14 ± 0.10 4.51 ± 0.11 3.89 ± 0.49
Left ventricular end-systolic dimension (mm) 2.17 ± 0.09 2.16 ± 0.24 3.02 ± 0.08† 1.92 ± 0.42*
Fractional shortening (%) 48.7 ± 1.5 48.0 ± 4.5 33.0 ± 0.2† 50.9 ± 5.0**
Ejection time corrected for HR (s) 51.5 ± 2.1 50.8 ± 2.5 48.3 ± 0.4 51.2 ± 3.2
Peak aortic velocity corrected for HR (cm/s) 95.4 ± 4.6 99.8 ± 2.1 91.7 ± 8.5 99.5 ± 14.2
Velocity of circumferential shortening corrected for HR (circ/s)
9.47 ± 0.46
9.45 ± 0.44
6.84 ± 0.00†
9.94 ± 0.52*

  • ↵* P < 0.01 compared with DOX + vehicle.

  • ↵** P < 0.05 compared with DOX + vehicle.

  • ↵† P < 0.05 compared with all other groups.