TABLE 3

Association of DCK SNPs with DCK mRNA expression in lymphoblast cell lines from subjects with European (CEPH) and African (YRI) ancestry

Genotype data was not available for Group2Y, Group3Y, and 29377 SNPs in 7, 10, and 1 YRI sample, respectively.


Polymorphism

Phenotype I DCK mRNA Expression

Phenotype II Ara-CTP (nmol/2 × 107 Leukemic Cells
CEPH (n = 85)
YRI (n = 90)
AML Patients Receiving Ara-C-Continuous Infusion Arm
Genotype
Mean ± S.D.
Genotype
Mean ± S.D.
Genotype
Mean ± S.D.
Group 1/block 1 represented by 3122 C>T CC (n = 75) 84 ± 37 CC (n = 7) 163 ± 27
CT (n = 10) 57 ± 18 CT (n = 27) 134 ± 44
TT (n = 56) 130 ± 39
CC vs. CT, *p = 0.02 CC vs. CT + TT, *p = 0.04
35708 T>C TT (n = 75) 84 ± 37 TT (n = 6) 155 ± 44 TT (n = 18) 0.48 ± 0.35
CT (n = 10) 57 ± 18 CT (n = 27) 135 ± 41 CC + CT (n = 9) 0.22 ± 0.17
CC (n = 57) 130 ± 18
TT vs. CT, *p = 0.02 TT vs. CT + CC, p = 0.07 TT vs. CC + CT, *p = 0.04a
Group 2Y represented by 3547C>T and linked to A119G CC (n = 80) 136 ± 41
CT (n = 3) 170 ± 47
CC vs. CT, p = 0.16 (0.08b)
Group 3Y represented by 36113C>T CC (n = 75) 141 ± 41
CT (n = 5) 97 ± 22
CC vs. CT, *p = 0.01
-245 G>C GG (n = 85) 138 ± 42
GC (n = 5) 95 ± 26
GG vs. GC, *p = 0.01
29377 C>T CC (n = 86) 138 ± 41
CT (n = 3) 85 ± 6



CC vs. CT, *p = 0.03


  • * p < 0.05.

  • a Excludes the sample heterozygous for A119G.

  • b p value when the analysis was performed in 60 independent parents.