ED50 | ST91 | Delt II | Observed Combined | Theoretical Additive | Interaction | |||||
---|---|---|---|---|---|---|---|---|---|---|
nmol (±95% CI) | ||||||||||
α2AAR-WT | 0.054 (±0.028) | 0.29 (±0.13) | 0.007 (±0.004) | 0.18 (±0.06) | Synergistic* | |||||
α2A-D79N | 0.18 (±0.12) | 0.22 (±0.10) | 0.005 (±0.005) | 0.22 (±0.08) | Synergistic* | |||||
α2CAR-WT | 0.058 (±0.028) | 0.005 (±0.002) | 0.003 (±0.001) | 0.023 (±0.006) | Synergistic* | |||||
α2CAR-KO | 0.12 (±0.04) | 0.058 (±0.041) | 0.009 (±0.004) | 0.084 (±0.033) | Synergistic* |
↵* Indicates that the observed combined ED50 < theoretical additive ED50, p < 0.05, Student's t test.