TABLE 1

Primary structure and activity of selected CRF-related peptides

Amino acid residue sequence. Numbers indicate amino acid residue position, and boldface regions indicate sequence identity. Residues in italics indicate cyclic lactam bridge constraint. Abbreviations below follow International Union of Pharmacology nomenclature.

1
5
10
15
20
25
30
35
40
mUcn 3 F T L S L D V P T N I M N I L F N I D K A K N L R A K A A A N A Q L M A Q I
oCRF S Q E P P I S L D L T F H L L R E V L E M T K A D Q L A Q Q A H S N R K L L D I A
Stressin1-A
Ac-
P
P
I
S
L
D
L
T
fa
H
L
L
R
E
V
L
E
Xb
A
R
A
E
Q
L
A
Q
Q
E
H
S
K
R
K
L
Xb
E
I
I

  • mUcn 3, mouse Ucn 3; oCRF, ovine CRF; Ac, acetylation.

  • ↵ a f = d-Phe.

  • ↵ b X = norleucine.