Gene expressed differently in isochaihulactone-treated A549 cells
Human lung adenocarcinoma A549 cells were treated with vehicle (0.2% DMSO) or isochaihulactone for 48 h and gene expression was determined using microarray analysis.
Functional Classification and Accession No. | Representative Gene Name | Changeb |
|---|---|---|
| -fold | ||
| Signal transduction | ||
| NG_005645 | GABA receptor-associated protein-like 3 | 2.29 |
| NM_002222 | Inositol 1,4,5-triphosphate receptor, type 1 | 3.21 |
| BC 013992 | Mitogen-activated protein kinase 3 (MAPK3) | 2.05 |
| BC 031574 | Mitogen-activated protein kinase 14 (MAPK14) | 2.01 |
| NM 004864 | NSAID-activated gene 1 (NAG-1) | 12.5 |
| NM 031412 | GABAA receptor-associated protein-like 1 | 2.33 |
| NM 016215 | EGF-like-domain, multiple 7 | 2.09 |
| Transcript factor | ||
| NM 003131 | Serum response factor (c-fos) | 4.10 |
| NM 001964 | Early growth response-1 (EGR-1) | 6.10 |
| BC 128420 | Heat shock transcription factor 2 | 2.68 |
| Cytoskeleton | ||
| NM 053027 | Myosin, light polypeptide | 2.17 |
| NM 000366 | Tropomyosin 1 (α) | 2.13 |
| NM 004924 | Actinin, α4 | 2.32 |
| Cell cycle | ||
| BT 006630 | CDC28 protein kinase 2 | 2.27 |
| NM 003478 | Cullin 5 | 3.89 |
| BC 000312 | P21/WAF1 | 3.82 |
| NM 001799 | Cyclin-dependent kinase 7 | 2.18 |
| Apoptosis | ||
| NM 007106 | Ubiquitin-like 3 | 3.58 |
| BC 008320 | Endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.43 |
| NM 032992 | Caspase 6 | 2.01 |
| NP_061178 | FEM-1 | 1.89 |
| Growth factor | ||
| NM_013956 | Neuregulin-1 (NRG-1) | 4.37 |
| NM_002006 | Fibroblast growth factor-2 (FGF-2) | 1.74 |
a Genes listed were increased by ≥ 1.5-fold a measured by Affymetrix GeneChip Software comparisons of isochaihulactone-treated versus vehicle-treated A549 cells.