EC50 values for 5-HT-induced contraction of endothelium-intact rat aorta
Antagonist | EC50 Value |
|---|---|
| -log mol/l | |
| Vehicle | 5.8 ± 0.1 |
| KTZ (1 μM) | 6.4 ± 0.1* |
| KTZ (10 μM) | 6.4 ± 0.1* |
| KTZ (50 μM) | 6.8 ± 0.1*†‡ |
| Vehicle | 5.8 ± 0.1 |
| l-NNA (100 μM) | 6.8 ± 0.1§ |
| l-NNA (100 μM) + KTZ (10 μM) | 7.0 ± 0.1§¶ |
| Vehicle | 5.9 ± 0.1 |
| Apocynin (100 μM) + l-NNA (100 μM) + KTZ (10 μM) | 6.9 ± 0.2∥ |
↵* Statistically significant (p < 0.01) difference from vehicle.
↵† Statistically significant (p < 0.05) difference from KTZ (1 μM).
↵‡ Statistically significant (p < 0.05) difference from KTZ (10 μM).
↵§ Statistically significant (p < 0.001) difference from vehicle.
↵¶ Statistically significant (p < 0.01) difference from l-NNA (100 μM).
↵∥ Statistically significant (p < 0.01) difference from vehicle.