Compound | Dose (i.v. Bolus) | pA50 | Log Dose Ratio |
---|---|---|---|
Vehicle control | Predrug | 10.06 ± 0.08 | |
Vehicle | 10.06 ± 0.04 | 0.00 ± 0.06 | |
Vehicle + 2 h | 9.91 ± 0.04 | 0.15 ± 0.07 | |
JNJ-17156516 | Predrug | 10.08 ± 0.07 | |
2 μmol kg-1 | 9.15 ± 0.05 | 0.93 ± 0.09 | |
2 μmol kg-1 + 2 h | 8.95 ± 0.06 | 1.13 ± 0.09 | |
Dexloxiglumide | Predrug | 9.98 ± 0.05 | |
20 μmol kg-1 | 8.56 ± 0.10 | 1.42 ± 0.11 | |
| 20 μmol kg-1 + 2 h | 9.38 ± 0.09 | 0.60 ± 0.13 |