Comparison of [N-allyl-Dmt1]-endomorphin-1, [N-allyl-Dmt1]-endomorphin-2, naloxone, and naltrexone to evoke withdrawal from acute morphine dependence in mice
Results are presented as mean ± S.E.M. Wet dog shakes and paw tremors were rated using following scale: +++, very intensive; ++, moderate; –, not present.
Compound | Number of | Presence of | ||||
|---|---|---|---|---|---|---|
| Vertical Jumps | Fecal Boli | Paw Tremors | Wet Dog Shakes | |||
| [N-allyl-Dmt1]EM-1 | 0 | 0 | - | - | ||
| [N-allyl-Dmt1]EM-2 | 0 | 0 | - | - | ||
| Naloxone | 19 ± 5 | 3 ± 1 | ++ | ++ | ||
| Naltrexone | 32 ± 5 | 4 ± 1 | +++ | ++ | ||