TABLE 3

ID50 values of CS-526, omeprazole, and lansoprazole on NH3-, acidified ethanol-, and IND-induced AGML

The inhibitory effect of CS-526 was compared with that of omeprazole and lansoprazole by analysis of covariance.


Treatment

ID50 (95% CI)
NH3-AGML
HCl/EtOH-AGML
IND-AGML
mg/kg
CS-526 9.9 (4.2-25) <3.0a 7.4 (0.41-24)
Omeprazole >30a 11 (6.0-24) 18 (9.2-150)
P vs. CS-526 0.1021 0.0037 0.0467
Lansoprazole >30a 3.8 (N.D.)b 6.9 (3.9-10)
P vs. CS-526
0.0050
0.1929
0.6230
  • a The theoretical ID50 value seemed to be outside of the dose range used.

  • b Because the slope of the regression line was not significant, the 95% CI could not be determined (N.D.).