Change in the antisecretory effect of CS-526 by retention time into Heidenhain pouch
CS-526 (1 mg/kg) was administered into the Heidenhain pouch for various periods before histamine infusion. Data represent the mean ± S.E. obtained from three to six dogs.
Treatment | Total Gastric Acid Output | P Value | Inhibition |
|---|---|---|---|
| μEq / 120 min | % | ||
| Control | 3736.4 ± 443.3 | ||
| CS-526, 30 min | 1733.6 ± 656.4 | 0.0317 | 53.6 |
| CS-526, 60 min | 1469.8 ± 210.5 | 0.0159 | 60.7 |
| CS-526, 180 min | 413.5 ± 396.0 | 0.0011 | 88.9 |