IC50 values for CS-526, omeprazole, lansoprazole, and rabeprazole on H+,K+-ATPase and Na+,K+-ATPase
The ratio of IC50 values of CS-526 and other PPIs on Na+,K+-ATPase against H+,K+-ATPase was calculated by following equation: IC50 value of Na+,K+-ATPase/IC50 value of H+,K+-ATPase.
Compound | IC50 against H+,K+-ATPase | IC50 against Na+,K+-ATPase | Ratio | |||
|---|---|---|---|---|---|---|
| μM | ||||||
| CS-526 | 0.061 | 10.4 | 170.5 | |||
| Omeprazole | 11 | 718.6 | 65.3 | |||
| Lansoprazole | 12 | 278.2 | 23.2 | |||
| Rabeprazole | 1.7 | 53.7 | 31.6 | |||