ED50 values and 95% confidence limits of tapentadol and morphine in animal models of acute and chronic pain
Pain Model | Route | ED50 Value (95% Confidence Limits) | ||
|---|---|---|---|---|
| Tapentadol | Morphine | |||
| mg / kg | ||||
| Hot plate, mouse | i.p. | 11.8 (8.5-15.7) | 4.7 (3.8-5.8) | |
| Tail flick, rat | i.p. | 10.0 (7.9-12.2) | 5.8 (4.5-7.3) | |
| Writhing, mouse | i.v. | 0.7 (0.4-1.0) | 0.4 (0.3-0.5) | |
| Randall Selitto, rat | i.p. | 10.1 (8.6-12.0) | 5.6 (4.3-8.2) | |
| Mustard oil-induced visceral pain, rat | i.v. | 1.5 (0.5-2.3)a; 3.8 (2.8-4.8)b; 3.9 (2.3-5.7)c | 1.0 (0.8-1.3)a; 0.8 (0.4-1.1)b; 0.9 (0.7-1.0)c | |
| SNL neuropathy, rat | i.p. | 8.2 (3.8-14.5) | 4.6 (3.8-5.7) | |
| CCI neuropathy, rat | i.p. | ∼13.0 (N.D.) | 7.1 (5.7-9.4) | |
| Streptozotocin model, rat | i.p. | 8.9 (7.1-11.1) | 3.0 (1.8-4.0) | |