Brain and body weight at 24 h after drug treatment
Values are expressed as mean ± S.E.M. Δ Body weight = body weight at time of sacrifice minus body weight at time of drug (or vehicle) injection. The n number of vehicle and phenytoin groups was derived from total number of animals across several different experimental sets. In the case of topiramate, levetiracetam, and drug combination groups, only the maximum dose groups have been shown; lower doses induced less change in normal growth.
Drug | Dose | Δ Body Weight for 24 h | Brain/Body Weight Ratio × 100 |
|---|---|---|---|
| mg / kg | |||
| Vehicle (n = 36) | 0 | 2.22 ± 0.09 | 4.79 ± 0.10 |
| Phenytoin (n = 25) | 50 | 1.02 ± 0.12* | 5.04 ± 0.10 |
| Valproate (n = 8) | 400 | -0.20 ± 0.43* | 5.13 ± 0.17 |
| Phenobarbital (n = 10) | 75 | 0.48 ± 0.21* | 5.30 ± 0.11 |
| MK801 (n = 10) | 0.5 | 0.03 ± 0.26* | 5.21 ± 0.16 |
| Carbamazepine (n = 14) | 50 | 1.85 ± 0.12 | 4.57 ± 0.09 |
| Carbamazepine (n = 10) | 100 | 0.72 ± 0.23* | 5.19 ± 0.12 |
| Topiramate (n = 12) | 80 | 1.62 ± 0.23 | 5.01 ± 0.30 |
| Levetiracetam (n = 6) | 1000 | 2.13 ± 0.26 | 4.50 ± 0.07 |
| Carbamazepine + phenytoin (n = 10) | 50 + 50 | 0.78 ± 0.21* | 4.84 ± 0.09 |
| Topiramate + phenytoin (n = 8) | 80 + 50 | 0.55 ± 0.18* | 4.91 ± 0.33 |
| Levetiracetam + phenytoin (n = 8) | 500 + 50 | 0.91 ± 0.24* | 4.86 ± 0.17 |
| Levetiracetam + carbamazepine (n = 9) | 500 + 50 | 1.64 ± 0.16 | 4.38 ± 0.08 |
↵* Significantly different from control, p < 0.05.