Plasma levels of GW427353 attained following each void after initiation of acetic acid infusion in the dog following i.v. administration Values are mean ± S.E.M. in nanograms per milliliter. Values in parentheses are in micromolar.
Treatment | n | Void | ||||
|---|---|---|---|---|---|---|
| 4 | 5 | 6 | ||||
| GW427353 (1 mg/kg) | 3 | 2830 ± 542 (6.4) | 1949 ± 403 (4.4) | 1612 ± 347 (3.6) | ||
| GW427353 (3 mg/kg) | 7 | 4598 ± 685 (10.3) | 3123 ± 507 (7.0) | 2307 ± 356 (5.2) | ||