Plasma and brain levels reached in gerbils after administration (i.p.) of NK1R antagonists
| Compound | Tmax Plasma | Cmax Plasma | Tmax Brain | Cmax Brain |
|---|---|---|---|---|
| min | nM | min | nmol/kg | |
| Aprepitant | 120 | 772 ± 27 | 240 | 460 ± 26 |
| ZD6021 | 30 | 1174 ± 240 | 30 | 123 ± 14 |
| CP99,994 | 15 | 35 ± 6 | 15 | 942 ± 135 |