TABLE 2

Effects of nisoxetine and cocaine on behavioral and physiological indices of stress

Treatment	Self-Grooming	Scratching	Salivary Cortisol
			μg/dl
Nisoxetine (VEH)	0.51 ± 0.23	0.51 ± 0.11	25.7 ± 4.7
Nisoxetine (0.3 mg/kg)	0.17 ± 0.10	0.5 ± 0.29	22.5 ± 5.2
Nisoxetine (1.0 mg/kg)	0.08 ± 0.08	0.67 ± 0.67	24.6 ± 2.0
Nisoxetine (3.0 mg/kg)	1.25 ± 0.87	0.67 ± 0.45	24.5 ± 1.8
Cocaine (VEH)	0.68 ± 0.31	0.54 ± 0.17	23.1 ± 2.2^a
Cocaine (0.1 mg/kg)	0.17 ± 0.17	0.17 ± 0.1*
Cocaine (0.3 mg/kg)	0 ± 0*	0 ± 0*	22.9 ± 2.1^a
Cocaine (1.0 mg/kg)	0 ± 0*	0 ± 0*	22.4 ± 3.7^a