TABLE 1

In vitro potency of PF-670462 and literature standards

Data represent the mean ± S.E.M. for n = 3 to 5 determinations.

	CKI∈ Inhibition^a (IC₅₀)	PER3 Nuclear Translocation^b (EC₅₀)
	nM
PF-670462	7.7 ± 2.2	290 ± 39
IC261	30,700 ± 2280	N.D.
CKI-7	35,600 ± 3670	N.D.
D4476	270 ± 106	7610 ± 285

N.D., not determined; indicates that solubility and/or toxicity issues prevented reliable determination of an EC₅₀ value.
↵ a Kinase-Glo assay (see Materials and Methods).
↵ b ArrayScan (Cellomics) (see Materials and Methods).