TRO19622 brain and plasma levels after chronic subcutaneous administration
Weeks of Treatment | Dose | Plasma Levelsa | Brain Levels | Ratio Brain/Plasma |
|---|---|---|---|---|
| mg/kg s.c. | μg/ml | μg/g | ||
| 1 | 0.3 | 0.06 ± 0.006 | BLQ | |
| 3 | 0.55 ± 0.07 | 0.19 ± 0.02 | 0.35 | |
| 30 | 5.35 ± 1.19 | 1.23 ± 0.30 | 0.23 | |
| 6 | 0.3 | 0.06 ± 0.008 | BLQ | |
| 3 | 0.47 ± 0.01 | 0.24 ± 0.04 | 0.51 | |
|
| 30 | 5.85 ± 1.06 | 2.66 ± 0.84 | 0.45 |
BLQ, below the limit of quantification.
↵ a TRO19622 at 1 μg/ml corresponds to 2.5 μM.