Echocardiographic data for SCID-NOD mice treated with vehicle, 15 mg/kg/week HU-331, and 4.5 mg/kg/week doxorubicin
Control | HU-331 | Doxorubicin | |
|---|---|---|---|
| IVSWD (mm) | 0.625 ± 0.025 | 0.56 ± 0.174929 | 0.675 ± 0.047871 |
| LVEDD (mm) | 3.05 ± 0.17 | 3.05 ± 0.12 | 3.15 ± 0.21 |
| LVESD (mm) | 1.3 ± 0.09 | 1.4 ± 0.08 | 1.98 ± 0.03*** |
| LVPWD (mm) | 0.8 ± 0.04 | 0.75 ± 0.05 | 0.78 ± 0.03 |
| EF (%) | 91 ± 2.3 | 91 ± 1.0 | 75 ± 3.8* |
| FS (%) | 57 ± 4.1 | 56 ± 1.8 | 38 ± 3.5* |
| Heart rate (bpm) | 606 ± 28.2 | 611 ± 8.7 | 423 ± 49.7* |
bpm, beats per minute.
↵* P < 0.05; *** P < 0.001.