Echocardiographic data for nude mice treated with vehicle, 15 mg/kg/week HU-331, and 2.5 mg/kg/week doxorubicin
Control | HU-331 | Doxorubicin | |
|---|---|---|---|
| IVSWD (mm) | 0.50 ± 0.01 | 0.53 ± 0.03 | 0.57 ± 0.02 |
| LVEDD (mm) | 2.92 ± 0.20 | 2.77 ± 0.21 | 2.75 ± 0.22 |
| LVESD (mm) | 1.2 ± 0.07 | 1.3 ± 0.09 | 1.58 ± 0.11* |
| LVPWD (mm) | 0.75 ± 0.05 | 0.76 ± 0.07 | 0.65 ± 0.05 |
| EF (%) | 94 ± 0.7 | 93 ± 0.6 | 79 ± 1.7*** |
| FS (%) | 61 ± 0.9 | 61 ± 1.2 | 42 ± 2.2*** |
| Heart rate (bpm) | 702 ± 32.3 | 679 ± 45.7 | 591 ± 10.5* |
bpm, beats per minute.
↵* P < 0.05; *** P < 0.001.