TABLE 2

Relief of current inhibition by felodipine, verapamil, and diltiazem at a holding potential of –80 mV

The values are given as mean ± S.E.

Drug
Alone
With 300 nM Bay K8644
Ca
 Relative ICa,p
n b
C
Relative ICa,p
n
μM μM
Felodipine 0.1 0.87 ± 0.13 4 1 0.82 ± 0.23 3
Verapamil 2 0.64 ± 0.04* 4 2 0.85 ± 0.03* 4
Diltiazem
0.5
1.0 ± 0.06
2
0.5
0.92 ± 0.14
2

  • ↵* Significantly different from 1 (p < 0.01).

  • ↵ a Concentration of the antagonist.

  • ↵ b The n values represent number of experiments.