TABLE 1

Affinity of ELN441958 and peptidic antagonists for the native human bradykinin B1 receptor

Inhibition of radioligand binding to membranes prepared from IMR-90 human lung fibroblasts. See Fig. 2 for displacement curves. Data are means ± S.E.M. of at least three experiments.


Antagonist

Ki

Hill Slope
nM
ELN441958 0.26 ± 0.02 1.1 ± 0.1
DALKD 0.49 ± 0.06 0.98 ± 0.06
desArg10HOE140
15 ± 3
0.88 ± 0.07