Characteristics of mEPSCs
mEPSCs were recorded in CA1 pyramidal neurons in hippocampal slices at VH =–60 mV and +40 mV. There was a significant increase in mEPSC peak current amplitude in FZP-withdrawn neurons at VH =–60 mV. Peak current amplitude (Ipeak) was derived from the averaged events with a rise time <5 ms. Data listed as means ± S.E.M. (number of cells) were analyzed by a two-tailed unpaired Student's t test.
Group | RMP | VH = -60 mV | VH = +40 mV | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ipeak | Rise Time | Decay (τ) | Ipeak | Rise Time | Decay (τ) | ||||||
| mV | pA | ms | pA | ms | |||||||
| CON | 67.3 ± 0.8 (9) | 7.0 ± 0.3 (9) | 2.8 ± 0.2 (9) | 15.0 ± 1.0 (9) | 5.3 ± 0.2 (9) | 3.4 ± 0.4 (9) | 12.5 ± 3.0 (9) | ||||
| FZP | 64.8 ± 1.3 (11) | 8.3 ± 0.3 (11)* | 2.7 ± 0.1 (11) | 16.0. ± 1.1 (11) | 4.9 ± 0.3 (11) | 2.9 ± 0.2 (11) | 14.1 ± 3.5 (11) | ||||
RMP, resting membrane potential.
↵* Significant difference, p < 0.05.