Production ratio of S-8921G with UGT Supersomes
Human UGT Supersomes (0.1 mg protein/ml) and 50 μM [14C]S-8921 were incubated for 1 h at 37°C. Data represent the mean of two incubations, and the values in parentheses represent the individual data.
UGT Isoform | % Total | ||||||
|---|---|---|---|---|---|---|---|
| S-8921G | S-8921 | ||||||
| No enzyme | N.D. | (N.D., N.D.) | 100 | (100, 100) | |||
| 1A1 | 7.11 | (5.81, 8.40) | 92.9 | (94.2, 91.6) | |||
| 1A3 | 3.40 | (2.90, 3.89) | 96.6 | (97.1, 96.1) | |||
| 1A4 | N.D. | (N.D., N.D.) | 100 | (100, 100) | |||
| 1A6 | N.D. | (N.D., N.D.) | 100 | (100, 100) | |||
| 1A8 | 20.4 | (20.7, 20.0) | 79.6 | (79.3, 79.9) | |||
| 1A9 | 34.4 | (37.1, 31.8) | 65.6 | (62.9, 68.2) | |||
| 1A10 | 5.43 | (5.81, 5.04) | 94.6 | (94.2, 95.0) | |||
N.D., not detected.